Automated mass photometry

Automated mass photometry combines the ease and efficiency of automation with the high sensitivity and simplicity of Refeyn’s molecular mass measurement technology. The automated mass photometer frees up operator time and offers enhanced precision, enabling rapid measurement of multiple samples with low sample consumption. Automation is compatible with the TwoMP.

Key Features

1. Rapid, automated measurement of multiple samples

2. optimized for screening and titration assays

3. Highly reproducible data with a user-friendly software

4. Compatible with TwoMP unit

Highly reproducible results

The liquid-handling robot autonomously analyses 24 samples in as little as 90 minutes in a highly reproducible manner.A straightforward, repeated measurement of a sample containing the antibody IgG illustrates the precision of the automated mass photometer, which is reflected in the high degree of reproducibility of the resulting data (Fig. 1).

Figure 1A shows histograms of 12 repeated measurements of an IgG sample made using automated mass photometry. Across the wells that contain the sample, the measured mass (Fig. 1B) and total counts (Fig. 1C) show low variability.

Figure 1 . Automated mass photometry measurements are highly reproducible. Autonomously run mass photometry measurements show (A) the mass distributions of IgG forming monomers and dimers (inset: mass histograms for each well). The measured mass (B) and total counts (C) across the wells show low variability. 

Applications

1. Protein-protein interactions

2. DNA-protein interactions

3. Protein oligomerization

4. Complex formation

（Please refer to the product mannual for information details.）